What is Exo-V by Exocellure?
Exo-V is Exocellure's two-step, exosome-based recovery system, applied immediately after aesthetic procedures like microneedling, laser resurfacing, RF microneedling, and chemical peels to support the skin's natural healing response.
What is the source of Exo-V's exosomes?
Human-derived mesenchymal stem cell (MSC) exosomes, sourced from U.S. donor umbilical cords under regulated tissue procurement and donor screening standards.
Are these real exosomes, or synthetic?
Real, human-derived MSC exosomes. Every batch is verified by CD81 and TSG101 marker testing, which confirms the presence of genuine, intact exosomes with an undisturbed membrane, and rules out cellular contamination (Calnexin-negative).
What are exosomes, and why do they matter for skin recovery?
Nanoscale vesicles naturally secreted by living cells, carrying growth factors, proteins, and RNA: the signals that coordinate cellular repair and collagen synthesis. They work with the skin's own repair biology rather than stimulating it artificially.
What products make up the Exo-V Protocol?
Step 1: Exo-V Ultra Lipid Serum, applied immediately post-procedure. Step 2: Exo-V Soothing Repair Mask, a hydrogel sheet mask left on 15–25 minutes.
What are the key ingredients in the Serum?
Human-derived MSC exosomes, Collagen Hydrating Essence, Lecithin, and RNA.
What are the key ingredients in the Repair Mask?
Centella Asiatica Extract, Adenosine, Fibronectin, Oligopeptide-1 (EGF), and Decapeptide-4.
How many exosomes are in Exo-V?
Each batch is verified by CD81 ELISA at 2.24 × 1010 exosomes per mL. Each single-use 5 mL vial contains 10+ billion active exosomes.
Are Exo-V's exosomes individually encapsulated?
Yes, each exosome is individually encapsulated in a liposomal protectant to preserve its structure through to application.
Has Exo-V undergone independent third-party testing?
Yes, on every batch:
| Test | Method | Result |
|---|---|---|
| Endotoxin | Pyros Kinetic Flex | 0.134 EU/mL (Pass) |
| 14-Day Sterility | USP <62003> | No Growth (Pass) |
| Particle Diameter | Nanoparticle Tracking Analysis | 134.6 nm mean (Pass) |
| Exosome Concentration | CD81 ELISA | 2.24 × 1010 / mL |
| Active Biomarkers | Quantitative ELISA | TGF-β1, BMP-2, IL-10 confirmed |
How is exosome identity confirmed?
Via Western blot marker panel: CD81 and TSG101 (positive exosome markers) both detected, with Calnexin (a marker of cellular contamination) absent in every sample, confirming genuine, intact, uncontaminated exosomes. Concentration is independently confirmed at 2.24 × 1010 exosomes/mL by CD81 ELISA.
Is Exo-V suitable for all skin types?
Yes, clinically compatible across all Fitzpatrick skin types (I–VI), with no reported increased risk of pigmentation.
How long is Exo-V shelf-stable?
24 months at room temperature, independently verified with every parameter passing specification at every checkpoint from day 0 through 24 months.
Does Exo-V require refrigeration?
It's shelf-stable at room temperature for the full 24-month shelf life. If the storage environment rises above 77°F (25°C), refrigeration is recommended to maintain stability.
How is Exo-V different from lyophilized (freeze-dried) exosome products?
Freeze-dried exosomes must be rehydrated before use, a process that can degrade the lipid membrane. Exo-V's liquid-stabilized format is ready to use straight from the vial, with no reconstitution, no potency loss, and no cold chain required.
What procedures is Exo-V designed to support?
Microneedling, RF microneedling, CO2 laser resurfacing, Er:YAG laser, IPL/broadband light, chemical peels, dermaplaning, microdermabrasion, other energy-based treatments, advanced facials, and cryotherapy facials.
What's the general application protocol?
Apply immediately post-procedure, using hands or gloved fingertips (not cotton pads). Allow full absorption. Don't wipe off or dilute. Serum first, Repair Mask to finish.
What clinical results have been observed?
Reported case examples include a CO2 laser patient reaching near-complete recovery at 60 hours (vs. an expected 7–14 day downtime) and visible redness reduction within 10 minutes of application after RF microneedling.
Case reportWhat patents protect Exocellure's technology?
Four related U.S. filings covering Exocellure's exosome technology: two granted, two pending.
Which patents are granted?
US 11,931,458, exosome systems, products and methods (the stabilized liquid composition), filed 2021, granted March 2024. US 12,409,136, a continuation of that technology, filed 2024, granted September 2025.
Which patents are pending?
US 2026/0000607, filed June 2025. US 2025/0255812, filed 2025. Both are with the USPTO awaiting examination.
What do the two granted patents protect?
Exocellure's exosome encapsulation technology, the specific method used to preserve exosome structure and stability. Because it's patented, other companies can't use this same encapsulation approach to stabilize their own exosomes.
Will Exo-V change my treatment-room workflow?
It's single-use, requires no mixing or refrigeration, and is applied in under two minutes as the final step of any procedure.
How do I explain this to patients?
"This is Exo-V. It delivers real exosomes, your skin's own repair signals, right onto your skin after your treatment to support collagen renewal and help your skin regenerate faster."
Is there a home-care line for patients?
Yes, launching 2027, available exclusively through authorized Exocellure clinic partners, with early access for existing partners.
Where can I find full clinical documentation?
Full batch Certificates of Analysis and supporting lab/patent documentation are available on request through your Exocellure representative.