RESOLVING VESICLE FIELD 00%
Exocellure · The Vesicle Doc 04 · 08 · May · 2026

Cellular intelligence,
in liquid form.

A nano-vesicle, secreted by a stem cell, carrying the proteins and microRNA that tell skin to repair itself. We didn't invent it, we made it survive shipping.

Read the science →
Diameter
134.6 nm
Concentration
2+ billion / ml
Surface Marker
CD81+ verified
Stable
24 mo · 25 °C
Scroll
Section 01 · Origin

Born from a cell.
Carrier of its memory.

When a mesenchymal stem cell needs to send instructions, repair this scar, calm this inflammation, build this collagen, it doesn't shout. It packages a microscopic copy of its own intent into a vesicle, seals it with a lipid membrane, and releases it.

Call it a letter. The address is written in surface proteins. The message is written in microRNA and growth factors. The skin reads it, and acts.

Every exosome is a cell speaking in a language that other cells were built to hear.
109+
Exosomes per ml of Exo-V serum
~134 nm
Mean diameter, our serum (NTA)
90 min
Cellular activity window
12+
Distinct cargo molecule classes
Section 02 · Anatomy

A 134-nanometer
vesicle.

Drag to rotate. Click a layer to isolate it. The four concentric structures are what our patents protect, without all four intact, the vesicle is just biological debris.

01 Polymer-polymer matrix PA-01 · pending
02 Lecithin liposome P-01 · US 11,931,458
03 CD81+ tetraspanins T-02 · 134.6 nm · NTA
04 Regenerative cargo miRNA · growth factors
Drag · Click layers
Ø 134.6 NM · CD81+ SCALE · 1 : 4×10⁶
Section 03 · Cargo

Twelve molecules.
One delivery.

Inside each Exocellure vesicle: a curated cassette of regenerative signals. Anti-inflammatory, pro-regenerative, anti-fibrotic, packaged together because that's how a healthy stem cell actually talks.

The list below isn't aspirational. Every entry is verified by ELISA, mass spec, or NTA on every production lot.

2+B
CD81+ vesicles per ml · ELISA
12+
Distinct molecules per vesicle
miRNA-21 Anti-fibrotic · 22 nt TGF-β1 Collagen synthesis BMP-2 Tissue regeneration IL-10 Anti-inflammatory cytokine miRNA-146a NF-κB modulator VEGF-A Microvascular signaling miRNA-29b Collagen homeostasis CD81 / CD9 / CD63 Surface tetraspanin signature
Section 04 · Mechanism

How a cell
tells its neighbor.

PARENT · MSC TARGET · DERMAL FIBROBLAST
01Release
A stem cell buds a vesicle.
Inside an MSC, a section of the inner membrane folds inward, captures cargo, and pinches off into a multivesicular body. When the cell is healthy, the body fuses with the cell wall and releases its vesicles into the surrounding tissue.
02Transit
It drifts to a target.
Surface tetraspanins, CD81, CD9, CD63, act as an address. Receptors on dermal fibroblasts recognize the signature and recruit the vesicle from extracellular fluid into direct contact.
03Fusion
It merges with the target.
The lipid bilayer of the vesicle fuses with, or is taken up into, the membrane of the target cell. Either path delivers the cargo inside, intact.
04Effect
The skin responds.
microRNA reduces inflammatory pathways. Growth factors push collagen and elastin transcription. The fibroblast, for the next 90 minutes, behaves like a younger version of itself.
Section 05 · The Problem

The reason
most exosomes fail.

A vesicle is held together by surface tension between two lipid sheets. Move it from −80 °C to room temperature and that tension relaxes. The membrane cracks. The cargo leaks. The product still says "exosome" on the label.

Toggle the panel, watch what happens to an unprotected vesicle versus the same vesicle inside our matrix. Same biology. Different shipping container.

Standard · without protection
Membrane degrades within 24–72 hours at 25 °C. Cargo leaks. Vesicle becomes biological debris.
Exocellure · stabilized matrix
Polymer-polymer matrix preserves bilayer tension. Cargo retained. CD81+ verified at 24 months.
STANDARD Bilayer integrity
100.0%
Section 06 · The Stabilization

We protect every layer.

Three patents granted, one pending, each addressing one specific layer of the vesicle. Together they're not a formulation. They're a fortified perimeter.

01
Polymer-polymer matrix
Sulfated polysaccharide ionically crosslinked with cationic poly-L-lysine. A porous outer shell that buffers osmotic pressure and traps free water away from the vesicle membrane.
PA-01 · Filed Jun 2025
Pending
02
Lecithin liposome
A co-bilayer engineered to share lipid neighbors with the native exosome membrane. Equalizes surface tension so room-temperature thermal motion cannot open a pore.
P-01 · US 11,931,458 B2 · Granted Mar 2024
Granted
03
CD81+ tetraspanins
Buffer chemistry tuned to maintain CD81 / CD9 / CD63 conformation, the recognition address. Lose the conformation, lose target-cell recognition, lose the activity.
T-02 · Application pending · USPTO
Pending
04
Regenerative cargo
RNAse-inhibitor and antioxidant blend that protects miRNA from degradation and growth-factor proteins from oxidation across the 24-month shelf life. Verified by ELISA on every production lot.
C-01 · US 12,409,136 B2 · Granted Sep 2025
Granted
Granted
2
USPTO · 2024–2025
Pending
2
USPTO · 2025
Layers Protected
4 / 4
Full perimeter
Verified Shelf-life
24 mo
25 °C · ACS
Section 07 · In the Skin

What it does
once it gets there.

Three measurable shifts in dermal biology, beginning within 90 minutes of application and persisting for the lifetime of the new collagen our cargo signals into existence.

Reduces inflammation

miRNA-146a and IL-10 dampen NF-κB signaling in resident immune cells. Visible reduction in erythema and post-procedure redness.

  • Post-laser recovery
  • Rosacea-prone skin
  • Acute irritation
Rebuilds collagen

TGF-β1 and BMP-2 increase pro-collagen I and III transcription in dermal fibroblasts. Density gain measurable by ultrasound dermography at 60 days.

  • Lines · static & dynamic
  • Loss of skin thickness
  • Stretch · scar remodeling
Restores barrier

VEGF-A and miRNA-21 modulate microvascular tone and lipid synthesis. TEWL (transepidermal water loss) reduces; ceramide composition normalizes.

  • Compromised barrier
  • Chronic dryness
  • Climate stress
Partner

Available to licensed
practitioners.

Exocellure ships only to verified medical aesthetics, dermatology, and surgical practices. Request the Protocol Kit and we'll route the rest.

Request Protocol Kit → Back to Home ↑
2 USPTO patents · granted
24 mo · 25 °C · ACS verified
CD81+ · 2+B / ml
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